| 摘要 |
The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.; |
| 主权项 |
1. A compound of formula Ia, wherein X is NH; Y is CH; R1 is H, C3-C7heterocycloalkyl, substituted C3-C7heterocycloalkyl, or COOR5, SOOR5, or CONR6R7; R2 is halogen; R3 is NHSO2R4; R4 is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R5 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; R6 and R7 are independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; or R6 and R7 are taken together with the nitrogen atom to form C3-C7heterocycloalkyl or substituted C3-C7heterocycloalkyl; n is 0, 1 or 2; m is 0 or 1; or a pharmaceutically acceptable salt, ester, or tautomer thereof. |
