Systems and Methods for Quantitative Doppler Optical Coherence Tomography

摘要

Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

主权项

1. A method of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system, the method comprising:
obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam; obtaining a second OCT scan of the retina, the second OCT scan being within an area defined by the obtained first OCT scan and including a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina; determining an optical phase change from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan; determining an angle of the retinal blood vessel associated with the optical phase change, the angle being measured relative to a direction of transmission of the OCT scan beam; and computing a quantitative measure of vessel blood flow using the optical phase change and the vessel angle relative to the direction of the OCT scan beam, wherein at least one of the steps of the method are performed by at least one processor.