| 发明名称 |
INDUSTRIAL METHOD FOR THE PREPARATON OF HIGH-PURITY METHIOZOLIN |
| 摘要 |
Provided is an industrial method for the preparation of [5-{(2,6-difluorobenzyloxy)methyl}-4,5-dihydro-5-methyl-3-(3-methylthiophene-2-yl)-isoxazole](common name: methiozolin) represented by Formula 1 that is a herbicidal substance in high-purity. |
| 申请公布号 |
US2015158852(A1) |
申请公布日期 |
2015.06.11 |
| 申请号 |
US201314398114 |
申请日期 |
2013.03.18 |
| 申请人 |
Moghu Research Center Ltd. ;Korea Research Institute of Chemical Technology |
发明人 |
Ko Young Kwan;Koo Dong Wan;Woo Jae Chun;Ryu Jae Wook;Koo Suk Jin;Hwang Ki Hwan;Lee Dong Guk;Chung Kun Hoe;Jeon Man Seok;Kim Sung Hun;Lim Jong Su;Cho Nam Gyu |
| 分类号 |
C07D413/04;B01J31/02 |
主分类号 |
C07D413/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the preparation of high-purity methiozolin (Formula 1), the method comprising reaction of 4,5-dihydro-5-methyl-3-{(3-methylthiophene-2-yl)-isoxazole-5-yl}methanol represented by Formula 2 below with 2,6-difluorobenzyl chloride (or bromide) represented by Formula 3 below in the presence of an alkali metal salt and a phase transfer catalyst in a mixed solvent system comprising water and an organic solvent at a temperature of 50 to 100° C., followed by crystallizing a concentrate of an isolated organic layer in a mixed solvent comprising water and alcohol or a mixed solvent comprising alcohol and aliphatic hydrocarbon: |
| 地址 |
Daejeon KR |
