| 发明名称 |
CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION |
| 摘要 |
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1):;;The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability. |
| 申请公布号 |
US2015158816(A1) |
申请公布日期 |
2015.06.11 |
| 申请号 |
US201514625046 |
申请日期 |
2015.02.18 |
| 申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
OHARA Yoshio;TAKADA Yasutaka;MATSUMOTO Hiroo;YOSHIDA Akihiro |
| 分类号 |
C07D215/14 |
主分类号 |
C07D215/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of storing a pitavastatin calcium salt, comprising:
maintaining a water content of the pitavastatin calcium salt at greater than 4% (w/w); wherein: the pitavastatin calcium salt is a compound according to formula (1):and
an X-ray powder diffraction pattern of the pitavastatin calcium salt, as measured using CuKα radiation, exhibits peaks at diffraction angles (20) of 10.40°, 13.20°, and 30.16°. |
| 地址 |
Tokyo JP |
