发明名称 SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
摘要 The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.;A compound of the general formula (II):;wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.;a pharmaceutically acceptable salt or a hydrate thereof.
申请公布号 US2015158833(A1) 申请公布日期 2015.06.11
申请号 US201514626044 申请日期 2015.02.19
申请人 SHIONOGI & CO., LTD. 发明人 KUGIMIYA Akira;FUJIOKA Masahiko;TACHIBANA Yuki;MURASHI Takami;ONODERA Naohiro
分类号 C07D295/26;C07D285/12;C07D277/28;C07D263/32;C07D261/18;C07D271/10;C07D307/68 主分类号 C07D295/26
代理机构 代理人
主权项
地址 Osaka JP