发明名称 |
PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE |
摘要 |
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae. |
申请公布号 |
WO2015082501(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
WO2014EP76313 |
申请日期 |
2014.12.02 |
申请人 |
VIROMETIX AG;SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE;UNIVERSITÄT BASEL;UNIVERSITÄT ZÜRICH |
发明人 |
GHASPARIAN, ARIN;ZUNIGA, ARMANDO;GEIB, NINA;TAMBORINI, MARCO;JUD, MAJA;PLUSCHKE, GERD;MARRERO NODARSE, ANIEBRYS;ROBINSON, JOHN ANTHONY |
分类号 |
C07K14/315;A61K39/00;A61K39/085;A61K39/09 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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