发明名称 |
METHODS TO PREDICT PROGRESSION OF BERRET'S ESOPHAGUS TO HIGH GRADE DYSPLASIA ESOPHAGEAL ADENOCARCINOMA |
摘要 |
In some embodiments, a method for aiding prediction of the likelihood of progression from Barrett's esophagus to high grade dysplasia or esophageal adenocarcinoma in a subject, is disclosed. The method can include (a) providing an oesophagal sample from said subject (b) determining if said sample stains abnormally with Aspergillus oryzae lectin; (c) determining if there is a DNA content abnormality in said sample; and (d) determining if there is low grade dysplasia in said sample; wherein if (b) is abnormal and (c) is abnormal and low grade dysplasia is present, then an increased likelihood of progression is determined. The disclosed subject matter also relates to an apparatus, and to different uses of certain materials. |
申请公布号 |
US2015160220(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
US201314401725 |
申请日期 |
2013.05.16 |
申请人 |
Medical Research Council |
发明人 |
Fitzgerald Rebecca;Bird-Lieberman Elizabeth |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
1. A method for aiding prediction of the likelihood of progression from Barrett's esophagus to high grade dysplasia or esophageal adenocarcinoma in a subject, the method comprising
(a) providing an oesophagal sample from said subject (b) determining if said sample stains abnormally with Aspergillus oryzae lectin; (c) determining if there is a DNA content abnormality in said sample; and (d) determining if there is low grade dysplasia in said sample; wherein if (b) is abnormal and (c) is abnormal and low grade dysplasia is present, then an increased likelihood of progression is determined. |
地址 |
Swindon, Wiltshire GB |