SYSTEM AND METHOD FOR FREEZE-DRYING AND PACKAGING

摘要

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

主权项

1. A system, comprising:
a flexible container defined by a height of a first dimension and a width of a second dimension, the height having an intermediate location separating the flexible container into a first portion and a second portion; a membrane, located within the first portion, configured to transmit air or solvent vapor out of, and resist liquid or contaminant passage into, the flexible container; and a membrane frame, coupled to both the membrane around its perimeter and a portion of the flexible container and engaged with at least one column member, the at least one column member configured to support the membrane and the membrane frame a spaced distance from one or more contents receivable within the flexible container.