| 主权项 |
1. A stabilized, low viscosity protein composition for topical application and transdermal delivery of an active agent for therapeutic use or cosmetic improvement in humans, said composition comprising a hydrogel forming combination of collagen, elastin, or a combination thereof, one or more absorption enhancers selected from a groups consisting of short chain alcohols, long chain alcohols, or polyalcohols, amines and amides, comprising urea, amino acids or their esters, amides, AZONE(R), derivatives of AZONE(R), pyrrolidones, or derivatives of pyrrolidones, terpenes and derivatives of terpenes, fatty acids and their esters, macrocyclic compounds, tensides, sulfoxides, liposomes, transfersomes, lecithin vesicles, ethosomes, water surfactants polyols, small molecule tri, tetra, penta, hexa, septa and octa peptides, Acetyl Hexapeptide-3 Cosmetic Topical Peptide, Melanotan II, ACVR2B (ACE-031), Argireline AcetateArgireline, Matrixyl Acetate (palmitoyl pentapeptide, peptide GHK spontaneously complexes with copper, Palmitoyl Tetrapeptide-3, and derivatives and analogues, (e.g., Argireline NP, Acetyl Glutamyl Heptapetide, Matrixyl, Snap-8, Syn-Tacks, Syn-Coll, Syn-Hycan, Leuphasyl, Pepha-Tight, Tego Pep 4-17 and Trylagen) and a pharmaceutically acceptable buffer capable of providing a buffered pH range to the composition of between about pH 5 and about pH 6, sodium chloride and at least one therapeutic or cosmetic concentration of an active agent encapsulated in a micelle formed by a combination of surfactants, solvents and stabilizers and wherein said protein composition is stable in low viscosity form at room temperatures of between 10 and 30 degrees C. for a period in excess of six months. |
