发明名称 METHOD FOR THE SYNTHESIS OF IRINOTECAN
摘要 The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (i.e. iriniotecan), comprising: (a) preparing 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptotecin; and (b) selectively ethylating the compound of step (a) at the 7-position, thus resulting in the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. The present invention is further directed to the use of 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. 7-des-ethyl-irinotecan) as intermediate in a method for the synthesis of irinotecan as described.
申请公布号 CA2924256(A1) 申请公布日期 2015.06.11
申请号 CA20142924256 申请日期 2014.11.24
申请人 SYNBIAS PHARMA AG 发明人 ZABUDKIN, ALEXANDER;MATVIENKO, VIKTOR
分类号 C07D491/22 主分类号 C07D491/22
代理机构 代理人
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