DETECTORS AND METHODS OF USING THEM

摘要

Certain embodiments described herein are directed to detectors and systems using them. In some examples, the detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In some instances, an analog signal from a non-saturated dynode is measured and cross-calibrated with a pulse count signal to extend the dynamic range of the detector.

主权项

1. A mass spectrometer comprising:
a sample introduction system; an ion source fluidically coupled to the sample introduction system; a mass analyzer fluidically coupled to the ion source; and a detector fluidically coupled to the mass analyzer, in which the detector comprises a plurality of dynodes, in which at least two dynodes of the plurality of dynodes are each electrically coupled to a respective electrometer, in which the detector is configured to measure a non-saturated analog signal from one of the at least two dynodes electrically coupled to its respective electrometer, in which the detector is configured to count pulses to provide a pulse count signal, and in which the detector is configured to cross-calibrate the measured non-saturated analog signal with the pulse count signal.