METHOD FOR DIAGNOSING SKIN DISEASE BASED ON IN VIVO SKIN IMAGING

摘要

A method for examining skin tissue of a subject based upon in vivo skin imaging includes a harmonic generation microscopy (HGM) device. The HGM device is configured for observing the skin tissue and forming sectioned images of the skin tissue of second harmonic generation (SHG), third harmonic generation (THG), or combination of the SHG and the THG of an excitation light scanning the skin tissue. The method further includes a step to determine whether the morphological feature of the skin tissue is related to a skin disease.

主权项

1. A method for examining skin tissue of a subject based on in vivo skin imaging, the method comprising:
providing a harmonic generation microscopy (HGM) device; obtaining at least one sectioned image of the skin tissue of the subject by using the HGM device, wherein the at least one sectioned image is formed through signals of second harmonic generation (SHG), third harmonic generation (THG), or combination of the SHG and THG from an excitation light having a wavelength in a range from about 1200 nm to 1330 nm and being used by the HGM device to in vivo scan the skin tissue; and identifying and analyzing at least one morphological feature of the skin tissue by processing the at least one sectioned image.