ANTIGEN-BINDING MOLECULES, THE ANTIGEN-BINDING ACTIVITY OF WHICH VARIES ACCORDING TO THE CONCENTRATION OF COMPOUNDS, AND LIBRARIES OF SAID MOLECULES

摘要

The problem to be solved is to provide: target tissue-specific antigen-binding molecules, antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of non-natural compounds, a library containing a plurality of said different antigen-binding molecules; a pharmaceutical composition containing said antigen-binding molecule; a method for screening for said antigen-binding molecule; and a method for producing same. The inventors of the present invention discovered that by preparing antigen-binding domains, the antigen-binding activity of which depends on the concentration of low-molecular weight compounds, or an antigen-binding molecule containing the antigen-binding domains, and by further creating said antigen-binding domain or library containing the plurality of said different antigen-binding domains, and using said library, it is possible to solve this problem. By using the antigen-binding molecule of the present invention, it is possible to specifically treat disorders originating in target tissue by specifically treating target tissue.