发明名称 |
G-PROTEIN COUPLED RECEPTOR AGONISTS AND METHODS |
摘要 |
Peptide-grafted antibodies having agonist activity against a Class B GPCR and their uses, and methods for identifying same. Mammalian cell lines for high-throughput screening for agonists of a Class B GPCR are also provided that comprise a stably integrated recombinant nucleic acid construct comprising a reporter gene under control of a cAMP responsive promoter, the reporter gene encoding a cell surface expressed protein, and a stably integrated recombinant nucleic acid construct comprising a sequence encoding a Class B GPCR under control of a constitutive promoter. |
申请公布号 |
CA2932325(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
CA20142932325 |
申请日期 |
2014.12.04 |
申请人 |
INNOVATIVE TARGETING SOLUTIONS INC. |
发明人 |
GALLO, MICHAEL;KANG, JASPAL SINGH;PIGOTT, CRAIG ROBIN;LIN, ABBY YU CHEN |
分类号 |
C07K19/00;C07K14/575;C07K14/605;C07K16/28;C12N5/10;C12N15/13;C12N15/62;C12N15/85;C12Q1/68;C40B40/02;C40B50/06;G01N33/567 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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