发明名称 |
METHOD OF DIAGNOSING NEOPLASMS |
摘要 |
The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers. |
申请公布号 |
US2015159223(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
US201414540583 |
申请日期 |
2014.11.13 |
申请人 |
CLINICAL GENOMICS PTY. LTD. ;COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION |
发明人 |
LAPOINTE Lawrence Charles;DUNNE Robert;YOUNG Graeme P.;LOCKETT Trevor John;WILSON William J. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual, said method comprising measuring the level of expression of one or more genes or transcripts selected from:
(i) the gene, genes or transcripts detected by Affymetrix probeset ID: 227475_at (ii) FOXQ1 in a biological sample from said individual wherein a higher level of expression of the genes or transcripts of group (i) or group (ii) relative to control levels is indicative of a neoplastic large intestine cell or a cell predisposed to the onset of a neoplastic state, wherein control levels are expression levels of the genes or transcripts of group (i) and/or group (ii) in a non-neoplastic cell. |
地址 |
North Ryde AU |