| 主权项 |
1. A compound having Formula If:wherein:
T1 is a phosphorus moiety having the formula: Ra and Rc are each, independently, protected hydroxyl, protected thiol, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy, protected amino or substituted amino; Rb is O or S; M1 is H, OH or OR1; M2 is OH, OR1 or N(R1)(R2); each R1 and R2 is, independently, C1-C6 alkyl or substituted C1-C6 alkyl; r is 0 or 1; A has one of the formulas: Q1 and Q2 are each, independently, H, halogen, C1-C6 alkyl or substituted C1-C6 alkyl; Q3 is O, S, N(R5) or C(R6)(R7);each R5, R6 and R7 is, independently, H, C1-C6 alkyl, substituted C1-C6 alkyl or C1-C6 alkoxy;
Bx1 is a heterocyclic base moiety; G is H, OH, halogen or O—[C(R8)(R9)]n—[(C═O)m—X1]j—Z; each R8 and R9 is, independently, H, halogen, C1-C6 alkyl or substituted C1-C6 alkyl; X1 is O, S or N(E1); Z is H, halogen, C1-C6 alkyl, substituted C1-C6 alkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl, substituted C2-C6 alkynyl or N(E2)(E3); E, E2 and E3 are each, independently, H, C1-C6 alkyl or substituted C1-C6 alkyl; n is from 1 to about 6; m is 0 or 1; j is 0 or 1; each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ1, N(J1)(J2), =NJ1, SJ1, N3, CN, OC(═X2)J1, OC(═X2)—N(J1)(J2) and C(═X2)N(J1)(J2); X2 is O, S or NJ3; each J1, J2 and J3 is, independently, H or C1-C6 alkyl; and when j is 1 then Z is other than halogen or N(E2)(E3). |
