Methods Of Identifying And Treating Poor-Prognosis Cancers

摘要

The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.

主权项

1. A method, comprising:
a) administering a chemotherapeutic agent to a patient exhibiting a tumor comprising a plurality of cells that are cancerous or suspected of being cancerous; b) developing a plurality of chemoresistant cancerous cells or suspected of being cancerous cells in said tumor as a result of said administered chemotherapeutic agent; and c) administering a combination of said chemotherapeutic agent and a metadherin activity inhibiting small organic molecule, wherein the development of said plurality of chemoresistant cancerous cells or suspected of being cancerous cells in said tumor is reduced.