发明名称 |
COMPLEX CHROMOSOME ENGINEERING FOR PRODUCTION OF HUMAN ANTIBODIES IN TRANSGENIC ANIMALS |
摘要 |
The invention relates to large-scale production of human antibodies by transgenic animals with high production of fully human IgG up to >10 g/L in sera with human IgG1 subclass dominancy. This invention also supports a feasibility of complex chromosome engineering for complicated genetic studies in non-murine mammalian species. |
申请公布号 |
EP2880055(A1) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20130747631 |
申请日期 |
2013.08.05 |
申请人 |
SAB, LLC |
发明人 |
KUROIWA, YOSHIMI;MATSUSHITA, HIROAKI;SANO, AKIKO |
分类号 |
C07K16/00;A01K67/027;C12N15/85;C12N15/87;C12N15/90 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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