发明名称 |
USE OF HUMANIZED MICE TO DETERMINE TOXICITY |
摘要 |
<p>The invention is directed to a method of determining whether an agent causes immune toxicity in a human comprising administering the agent to a non-human mammal that has been engrafted with human hematopoietic stem cells (HSCs) and administered one or more human cytokines; and determining whether the agent causes immune toxicity in the non-human mammal. If the agent causes immune toxicity in the non-human mammal then the agent causes toxicity in a human. The invention is also directed to a method of determining whether administration of an agent causes cytokine release syndrome in an individual in need thereof comprising administering the agent to a non-human mammal that has been engrafted with HSCs and administered one or more human cytokines; and determining whether the agent causes cytokine release syndrome in the non-human mammal. If the agent causes cytokine release syndrome in the non-human mammal then the agent will cause cytokine release syndrome in the human.</p> |
申请公布号 |
EP2788758(A4) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20120854884 |
申请日期 |
2012.12.05 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BOUGUERMOUH, SALIM;KHOURY, MAROUN;CHEN, QINGFENG;CHEN, JIANZHU |
分类号 |
G01N33/53;A01K67/00;A01K67/027 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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