发明名称 |
COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR REPAIRING CARTILAGE DAMAGE |
摘要 |
The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof. |
申请公布号 |
EP2734622(A4) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20120814129 |
申请日期 |
2012.07.19 |
申请人 |
VIVOSCRIPT, INC.;OREGON HEALTH AND SCIENCE UNIVERSITY |
发明人 |
ZHU, YONG;WU, SHILI;BAO, JUN;CHU, CONG-QIU |
分类号 |
C12N15/11;A61K38/16;A61L27/38;C07K14/00;C07K19/00;C12N5/077 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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