发明名称 |
COMPOSITIONS AND METHODS FOR REGULATING NEUTROPHIL MOVEMENT AND NEUTROPHIL NUMBERS IN A BODY REGION |
摘要 |
<p>The disclosure relates to compositions including dipeptidyl peptidase-IV (DPPIV) as well as compositions including an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium autocrine proliferation repressor A (AprA) region. The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a DPPIV composition to the body region in an amount and for a time sufficient to suppress neutrophil movement into the body region or enhancing neutrophil movement out of the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium AprA region.</p> |
申请公布号 |
EP2741764(A4) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20120823790 |
申请日期 |
2012.08.10 |
申请人 |
THE TEXAS A&M UNIVERSITY SYSTEM |
发明人 |
GOMER, RICHARD;PHILLIPS, JONATHAN;HERLIHY, SARAH;MAHARJAN, ANU;PILLING, DARRELL |
分类号 |
A61P25/00;A61K38/48;A61P11/00;A61P19/00;A61P29/00 |
主分类号 |
A61P25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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