发明名称 |
FUNCTIONALISATION METHODS AND REAGENTS USED IN SUCH METHODS USING AN AZAISATOIC ANHYDRIDE OR ONE OF THE DERIVATIVES OF SAME, BIOLOGICAL MOLECULES THEREBY TREATED, AND KITS |
摘要 |
<p>The present invention relates to a method of functionalization of at least one ribonucleic acid (RNA) molecule, contained in a liquid sample, which includes the following steps: a) providing at least: one binding molecule consisting of an aza-isatoic anhydride or a derivative thereof, one group of interest, and one linkage joining the binding molecule to the group of interest, b) reacting the anhydride function of the binding molecule with at least one hydroxyl group carried: in position 2′of the ribose of one of the RNA nucleotides, and/or in position(s) 2′and/or 3′of the ribose of the nucleotide at the terminal 3′end of the RNA, and obtaining an aza-anthranilate that joins, by means of the linkage, the RNA to the group of interest.</p> |
申请公布号 |
EP2880016(A1) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20130744493 |
申请日期 |
2013.07.26 |
申请人 |
BIOMÉRIEUX |
发明人 |
CAILLY, THOMAS;FABIS, FRÉDÉRIC;LAAYOUN, ALI;LAURENT, ALAIN;URSUEGUI, SYLVAIN |
分类号 |
C07D213/80;C07D495/04;C07D519/00;C07H21/00;C12Q1/68 |
主分类号 |
C07D213/80 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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