| 摘要 |
<p>Specific peptides (1), and their salts, derivatives and/or conjugates are new. Specific peptides of formula (1), and their salts, derivatives and/or conjugates are new. Cys-X1-X2-Tyr-Phe-Tyr-Thr-Ser-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X14-X15-Cys (1) X1 : Lys, Gln, Arg, His, Asn or is absent; X2 : Glu, Asp, Gln or is absent; X3 : Gly, Ser or ala; X4 : Lys, Leu or Arg; X5 : Ser, Cys, Gly or Thr; X6 : Ser, Gly or Thr; X7 : Asn or Gln; X8 : Pro, Tyr or Gly; X9 : Gly, Ala or Ser; X10 and X11 each : Ile, Val or Asn; X12 : Phe, Tyr, Ile, Val, Leu or Met; X13 : Ile, Val, Leu, Met or Phe; X14 : Thr, Gly, Ala, Ser or Tyr; X15 : Arg, Lys, Gln, His or Asn. . ACTIVITY : Antiinflammatory; Antiarteriosclerotic; Vasotropic; Hypotensive; Antiarthritic; Immunosuppressive; Dermatological; Antiasthmatic; Antiallergic. MECHANISM OF ACTION : RANTES antagonist; Platelet factor 4 antagonist; Gene therapy.</p> |
