Endothelin-1 receptor(s) based endothelin-1 sponge

摘要

Fusion polypeptides capable of binding endothelin-1 to form a non-functional complex are provided, including amino acid sequences of the fusion polypeptides. The fusion polypeptides will be linked to the Fc portion of human IgG1 to form dimers that will function as endothelin-1 antagonists (endothelin-1 sponge).