MEANS FOR CORRECTION OF PATHOLOGIC CHANGES OF VIABLE OFFSPRING, CAUSED BY CYTOSTATIC IMPACT ON MOTHER'S ORGANISM

摘要

FIELD: medicine.SUBSTANCE: to correct pathologic changes in the condition of viable offspring under a cytostatic impact the medication glutoxim is introduced to female rats in a dose of 50 mcg/kg 5 days before and 5 days after the introduction of the cytostatic medication vepesid. The latter is introduced once intravenously in a maximal tolerable dose, equal to 30 mg/kg. It has been established that glutoxim can be applied as means for the correction of pathologic changes in the viable offspring of rats, obtained from coupling 3 months after the cytostatic impact.EFFECT: application of glutoxim as the means of corrective therapy makes it possible to increase efficiency and reduce its side effects.6 dwg