| 发明名称 | Process for preparing triazole-containing ketolide antibiotics | ||
| 摘要 | The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A. | ||
| 申请公布号 | US9051346(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201113699020 | 申请日期 | 2011.05.20 |
| 申请人 | CEMPRA PHARMACEUTICALS, INC. | 发明人 | Pereira David E. |
| 分类号 | C07H17/08 | 主分类号 | C07H17/08 |
| 代理机构 | Brannon Sowers & Cracraft PC | 代理人 | Brannon Sowers & Cracraft PC |
| 主权项 | 1. A process comprising (a) the step of contacting a compound of formula (III)or a salt thereof, wherein Q in combination with the oxime oxygen forms an acetal or ketal, with an acylating agent to form a compound of formula (IV)or a salt thereof, wherein R is an acyl group; or (b) the step of contacting a compound of formula (IV), or a salt thereof, with a methylating agent, to form a compound of formula (V)or a salt thereof; or (c) the step of contacting a compound of formula (V), or a salt thereof, with a deoximating agent to form a compound of formula (II)or a salt thereof; or (d) any combination of (a), (b), and (c). | ||
| 地址 | Chapel Hill NC US | ||