Dithiolopyrrolones with therapeutic activity

摘要

The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.

主权项

1. A method of treating leukemia, non-small cell lung cancer, colon cancer, astrocytoma, glioblastoma, gliosarcoma, or melanoma comprising administering a therapeutically effective amount of a compound according to the formula: wherein X, Y and Z are defined as follows:CompoundXYZ00582,4-dimethoxy-phenylH3,5-di-trifluoromethylphenyl.