Process for the production of a pemetrexed salt

摘要

A process of making a pemetrexed salt comprising:
a) reacting a compound of formula II;
or an acid salt thereof, wherein each of R1 and R2 is independently a C1-C6 alkyl group, with an aqueous basic solution at a temperature of no more than 10° C. to obtain a first mixture comprising the pemetrexed salt;
b) isolating the pemetrexed salt from the first mixture.

主权项

1. A process of making a pemetrexed salt comprising:
a) reacting a compound of formula IIor an acid salt thereof, wherein each of R1 and R2 is independently a C1-C6 alkyl group, with an aqueous basic solution at a temperature of no more than 10° C. to directly obtain a first mixture comprising the pemetrexed salt, wherein the reaction mixture is a solution;
b1) adding an organic anti-solvent to the first mixture of step a) to form a second mixture; b2) adjusting the pH of the second mixture within a range from about 6.5 to about 9.5 to form a third mixture; and b3) separating the pemetrexed salt from the third mixture.