| 主权项 |
1. A method of treatment of diabetic neuropathy comprising administering to a human or animal in need thereof an effective amount of a compound of formula (I) in which D is N or C—R4, in which
R4 is hydrogen, fluorine, trifluoromethyl or (C1-C4)-alkyl, Ar is a group of the formula in which* is the linkage point,R5 is hydrogen, fluorine, chlorine, cyano, nitro, trifluoromethyl or (C1-C4)-alkyl,R6 is hydrogen or fluorine,R7 is halogen, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy or trifluoromethoxy,R8 is cyano or nitro,R9 is hydrogen, halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylthio or di-(C1-C4)-alkylamino, it being possible for the alkyl group in said (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio radicals in each case to be substituted up to three times by fluorine,
orphenyl, which may be substituted by halogen, (C1-C4)-alkyl or trifluoromethyl,R10 is hydrogen, halogen or (C1-C4)-alkyl,E is CH, C—R7 or N,andn is the number 0, 1 or 2,
it being possible in the case where the substituent R7 occurs more than once for its meanings to be identical or different, R1 is (C1-C4)-alkyl which may be substituted up to three times by fluorine, R2 is (C1-C6)-alkyl which may be substituted by (C3-C7)-cycloalkyl or up to three times by fluorine, or is a group of the formula —SO2—R11 in which
R11 is (C1-C6)-alkyl, trifluoromethyl, (C3-C7)-cycloalkyl, phenyl or 5- or 6-membered heteroaryl having up to two heteroatoms from the series N, O and/or S,
it being possible for phenyl and heteroaryl in turn each to be substituted once or twice, identically or differently, by halogen, cyano, nitro, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy and/or trifluoromethoxy, and R3 is hydrogen, fluorine, trifluoromethyl or (C1-C4)-alkyl, or a salt thereof. |
