发明名称 |
Conjugate based systems for controlled drug delivery |
摘要 |
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation. |
申请公布号 |
US9050370(B2) |
申请公布日期 |
2015.06.09 |
申请号 |
US201013145532 |
申请日期 |
2010.01.27 |
申请人 |
SMARTCELLS, INC. |
发明人 |
Zion Todd C.;Lancaster Thomas M. |
分类号 |
A61K38/28;A01N43/04;A61K31/70;A61K47/48 |
主分类号 |
A61K38/28 |
代理机构 |
|
代理人 |
Thampoe Immac J.;Reilly John David |
主权项 |
1. A conjugate comprising an insulin molecule conjugated to one or more ligands wherein at least one ligand is aminoethyltrimannose having the formula;wherein the conjugate is characterized in that, when the conjugate is administered to a mammal in the absence of an exogenous multivalent saccharide-binding molecule, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a saccharide. |
地址 |
Beverly MA US |