发明名称 |
Compositions employing alternative reading frame polypeptides for the treatment of cancer and infectious disease |
摘要 |
Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions that comprise ARF polypeptides. ARF polypeptides and ARF polypeptide-based compositions are useful in the treatment of cancer and infectious disease. |
申请公布号 |
US9051385(B2) |
申请公布日期 |
2015.06.09 |
申请号 |
US200912573685 |
申请日期 |
2009.10.05 |
申请人 |
DENDREON CORPORATION |
发明人 |
Graddis Thomas;Laus Reiner;Diegel Michael;Vidovic Damir |
分类号 |
A61K39/00;C07K14/47 |
主分类号 |
A61K39/00 |
代理机构 |
King & Spalding LLP |
代理人 |
King & Spalding LLP |
主权项 |
1. A polypeptide conjugate comprising an N-terminal moiety and a C-terminal moiety, wherein said N-terminal moiety comprises one or more ARF polypeptides and said C-terminal moiety comprises a polypeptide moiety that facilitates binding of said ARF polypeptide to an antigen presenting cell (APC),
and wherein each said ARF polypeptide comprises at least 9 amino acids of an ARF polypeptide encoded by a human tyrosine kinase receptor (hHER-2) polynucleotide represented by SEQ ID NO: 2 and has a sequence selected from SEQ ID NOs: 71-95 and fragments thereof comprising at least 9 amino acids. |
地址 |
Seattle WA US |