USE OF A SULFONAMIDE COMPOUND FOR IMPROVING THE PHARMACOKINETICS OF A DRUG
摘要
A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention.
申请公布号
CA2604799(C)
申请公布日期
2015.06.09
申请号
CA20062604799
申请日期
2006.04.14
申请人
TIBOTEC PHARMACEUTICALS LTD.
发明人
VAN 'T KLOOSTER, GERBEN ALBERT ELEUTHERIUS;WIGERINCK, PIET TOM BERT PAUL;DE MEYER, SANDRA;BAERT, LIEVEN ELVIRE COLETTE;DE KOCK, HERMAN AUGUSTINUS