| 发明名称 | Isolation and/or identification of stem cells having adipocytic, chondrocytic and pancreatic differentiation potential | ||
| 摘要 | The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof. | ||
| 申请公布号 | US9052316(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201012980092 | 申请日期 | 2010.12.28 |
| 申请人 | EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUM | 发明人 | Buehring Hans-Joerg;Treml Sabrina;Lammers Reiner |
| 分类号 | G01N33/531;G01N33/569;C07K16/28;C07K16/40;C12N5/0775 | 主分类号 | G01N33/531 |
| 代理机构 | Casimir Jones S.C. | 代理人 | Casimir Jones S.C. |
| 主权项 | 1. A method for isolating and/or identifying of stem cells with adipocytic, chondrocytic and pancreatic differentiation potential, wherein the method comprises the step of contacting a sample containing stem cells with an antibody which binds to the antigen TNAP (tissue non-specific alkaline phosphatase) and isolating and/or identifying the stem cells to which the antibody binding the TNAP antigen has bound, and wherein in addition a second antibody or functional, antigen-binding fragments of the second antibody, is contacted with said sample, wherein the second antibody binds to CD56. | ||
| 地址 | Tuebingen DE | ||