| 发明名称 | Method for inducing lymphoid tissue and modulating intestinal homeostasis | ||
| 摘要 | Methods and products for modulating the lymphoid system, especially intestinal homeostasis between intestinal lymphoid tissues and gut flora using ligands for NOD1 and/or CCR6. | ||
| 申请公布号 | US9050320(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201313840536 | 申请日期 | 2013.03.15 |
| 申请人 | INSTITUT PASTEUR | 发明人 | Eberl Gerard;Bouskra Djahida;Gomperts Boneca Ivo;Brezillon Christophe |
| 分类号 | A61K38/17;A61K39/395;A61K35/74;A61K38/16 | 主分类号 | A61K38/17 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A method for modulating intestinal homeostasis by generating adaptive lymphoid tissue comprising: administering to a subject in need thereof at least one agent that binds to CCR6 (chemokine receptor type 6) which is selected from the group consisting of murine β-defensin 3, human β-defensin 2, and C—C motif chemokine ligand 20, or a CCR6 binding portion thereof, wherein said at least one agent is administered in an amount sufficient to induce or enhance the formation of ILFs (isolated lymphoid follicles) in said subject compared to a control subject not receiving said agent. | ||
| 地址 | Paris FR | ||