| 发明名称 | Broad spectrum vaccine against non-typhoidal <i>Salmonella </i> | ||
| 摘要 | The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing an immune response in a subject comprising administering the attenuated strains and/or the conjugate vaccines of the invention. | ||
| 申请公布号 | US9050283(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201013144336 | 申请日期 | 2010.01.16 |
| 申请人 | University of Maryland, Baltimore | 发明人 | Levine Myron M.;Simon Raphael;Galen James;Tennant Sharon |
| 分类号 | A61K39/112;A61K39/00;A61K39/385;A61K45/00;A61K47/00 | 主分类号 | A61K39/112 |
| 代理机构 | Nevrivy Patent Law Group P.L.L.C. | 代理人 | Nevrivy Patent Law Group P.L.L.C. |
| 主权项 | 1. A method of inducing an immune response, comprising administering to a subject in need thereof an immunologically-effective amount of a Salmonella enterica serovar conjugate, wherein the conjugate consists essentially of an O polysaccharide (OPS) covalently linked to a flagellin protein, wherein the serovar is selected from the group consisting of S. Typhimurium and S. Enteritidis. | ||
| 地址 | Baltimore MD US | ||