Compositions comprising chitosan suitable for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome

摘要

The present invention relates to compositions comprising chitosan, in the form of drugs or food supplements, suitable for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome. Also described is their preparation. More generally, the invention concerns the use of chitosan for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome.

主权项

1. A method for comprehensive therapeutic treatment of metabolic syndrome comprising:
(a) identifying a patient as suffering from metabolic syndrome wherein at least three of the following parameters are positively assessed in said patient:
(i) waist circumference equal to or greater than 102 cm in men and equal to or greater than 88 cm in women,(ii) triglyceride level equal to or greater than 150 mg/dL,(iii) HDL cholesterol level less than 40mg/dL in men and less than 50 mg/dL in women,(iv) arterial blood pressure equal to or greater than 130/85 mm Hg, and(v) elevated basal fasting glucose equal to or greater than 100 mg/dL; and (b) administering to said patient suffering from metabolic syndrome a composition consisting essentially of chitosan, ascorbic acid and tartaric acid, wherein the ascorbic acid is in an amount between 1 and 10%, by weight based on the amount of the chitosan and said administering is carried out at a dosage effective to modify at least two of the three positively assessed parameters in the patient in the absence of dietary modification by said patient as follows:
(i) a waist circumference of less than 102 cm in men and less than 88 cm in women,(ii) a triglyceride level of less than 150 mg/dL,(iii) an HDL cholesterol level of equal to or greater than 40 mg/dL in men and equal to or greater than 50 mg/dL in women,(iv) an arterial blood pressure of less than 130/85 mm Hg, and(v) a non-elevated basal fasting glucose of less than 100 mg/dL.