Functional influenza virus like particles (VLPs)

摘要

The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

主权项

1. A vaccine comprising an influenza VLP and a pharmaceutically acceptable carrier or excipient,
wherein the VLP comprises influenza M1, HA and NA proteins, wherein the M1 protein is from an avian influenza virus, wherein the M1 protein is from a different strain of influenza virus than the influenza HA protein and the influenza NA protein; and wherein the vaccine induces substantial immunity to influenza virus infection in a human susceptible to influenza.