Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors

摘要

The present invention is directed to novel tricyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.;

主权项

1. A compound of structural formula I: or a pharmaceutically acceptable salts thereof; wherein
R1 is selected from the group consisting of C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C10cycloalkyl, benzyl, heterocycle and C1-C6alkylheterocycle; wherein the C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C10cycloalkyl, benzyl, heterocycle and C1-C6alkylheterocycle are unsubstituted or substituted with 1-3 substituents each independently selected from R5;R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C6 alkyl wherein the C1-C6 alkyl is unsubstituted or substituted with one or more substituents selected from R5; andR5 is selected from the group consisting of hydrogen, halogen, C1-C6alkyl, halogen-substitutedC1-C6alkyl, —OH, C1-C6alkylOH, halogen-substitutedC1-C6alkylOH, —OC1-C6alkyl, —Ohalogen-substitutedC1-C6alkyl, —COOH, —COOC1-C6alkyl, —C1-C6alkylCOOC1-C6alkyl, —C1-C6alkylCOOH, —OC1-C6alkylCOOH, —CN, C1-C6alkylCN, NH2, NHC1-C6alkyl, N(C1-C6alkyl)2, —NHCOOC1-C6alkyl, C1-C6alkylCONH2, —CONH2, —CONHC1-C6alkyl, —NHCOC1-C6alkyl, —CON(C1-C6alkyl)2, —NHSO2C1-C6alkyl, SO2aryl, —SO2C1-C6alkyl, C1-C6alkyl SO2C1-C6alkyl, aryl, —NHCOaryl, and —NHCOheterocycle.