| 主权项 |
1. A compound having Formula Ior a pharmaceutically acceptable salt thereof, wherein
W is alkyl, H, F, Cl, Br or I; X is C(O)R1, C(O)NHR1A, C(O)N(R1)2, NHC(O)R1A, NR1C(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, or NR1C(O)N(R1)2; wherein R1 is R2, R3, R4 or R5; R2 is aryl; R3 is heteroaryl; R4 is cycloalkyl, cycloalkenyl, or heterocyclyl; R5 is C1-C6 alkyl; each of which is unsubstituted or substituted with one or two independently selected R6, NH2 or CN; R6 is R7, R8, or R9; R7 is aryl; R8 is heteroaryl; R9 is cycloalkyl, cycloalkenyl, or heterocyclyl; wherein R1A is R2A, R3A, R4A or R5A; R2A is aryl; R3A is heteroaryl; R4A is cycloalkyl, cycloalkenyl, or heterocyclyl; R5A is C1-C6 alkyl; each of which is unsubstituted or substituted with one or two independently selected R6A, NH2 or CN; R6A is R7A; R8A; or R9A; R7A is aryl; R8A is heteroaryl; R9A is cycloalkyl, cycloalkenyl, or heterocyclyl; wherein the moieties represented by R2, R3, R4, R7, R8, R9, R3A, R4A, R7A, R8A, and R9A are independently unsubstituted or substituted with one or two or three or four of independently selected, R10, OR10, SR10, S(O)R10, SO2R10, NH2, NHR10, N(R10)2, C(O)R10, C(O)OR10, C(O)NH2, C(O)NHR10, C(O)N(R10)2, C(NOH)NH2, NHC(O)R10, NR10C(O)R10, NHSO2R10, NR10SO2R10, NHC(O)OR10, NR10C(O)OR10, NHSO2NH2, NHSO2NHR10, NHSO2N(R10)2, SO2NH2, SO2NHR10, SO2N(R10)2, NHC(O)NH2, NHC(O)NHR10, NHC(O)N(R10)2, NR10C(O)N(R10)2, NO2, OH, (O), C(O)H, C(O)OH, CN, CF3, OCF3, CF2CF3, F, Cl, Br or I; wherein the moiety represented by R2A is independently unsubstituted or substituted with one or two or three or four of independently selected, R10, OR10, SR10, S(O)R10, SO2R10, NH2, NHR10, N(R10)2, C(O)R10, C(O)OR10, C(O)NH2, C(O)NHR10, C(O)N(R10)2, C(NOH)NH2, NHC(O)R10, NR10C(O)R10, NHSO2R10, NR10SO2R10, NHC(O)OR10, NR10C(O)OR10, NHSO2NH2, NHSO2NHR10, NHSO2N(R10)2, SO2NH2, SO2NHR10, SO2N(R10)2, NHC(O)NH2, NHC(O)NHR10, NHC(O)N(R10)2, NR10C(O)N(R10)2, NO2, OH, (O), C(O)H, C(O)OH, CN, CF3, OCF3, or CF2CF3; R10 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl; Y is R12 or R13; R12 is aryl; R13 is heteroaryl; Z is alkyl, H, CF3, F, Cl, Br or I; wherein the moieties represented by R12 and R13 are independently unsubstituted or substituted with one or two or three or four of independently selected, R14, OR14, SR14, S(O)R14, SO2R14, NH2, NHR14, N(R14)2, C(O)R14, C(O)OR14, C(O)NH2, C(O)NHR14, C(O)N(R14)2, C(NOH)NH2, NHC(O)R14, NR14C(O)R14, NHSO2R14, NR14SO2R14, NHC(O)OR14, NR14C(O)OR14, NHSO2NH2, NHSO2NHR14, NHSO2N(R14)2, SO2NH2, SO2NHR14, SO2N(R14)2, NHC(O)NH2, NHC(O)NHR14, NHC(O)N(R14)2, NR14C(O)N(R14)2, NO2, OH, (O), C(O)H, C(O)OH, CN, CF3, OCF3, CF2CF3, F, Cl, Br or I; wherein each R14 is R15, R16, R17 or R18; R15 is aryl; R16 is heteroaryl; R17 is cycloalkyl, cycloalkenyl, or heterocyclyl; R18 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R19, OR19, SR19, S(O)2R19, NHS(O)2R19, C(O)OH, NH2, NHR19, N(R19)2, C(O)R19, C(O)OR19, C(O)NH2, C(O)NHR19, C(O)N(R19)2, NHC(O)R19, NR19C(O)R19, NHC(O)OR19, NR19C(O)OR19, OH, F, Cl, Br or I; wherein each R19 is R20 or R21; R20 is aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl; R21 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R22, OR22, C(O)OH, NH2, NHR22, N(R22)2, C(O)R22, C(O)NH2, C(O)NHR22, C(O)N(R22)2, NHC(O)R22, NR22C(O)R22, OH, F, Cl, Br or I; wherein each R22 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl; wherein the moieties represented by R15, R16, R17, and R20 are independently unsubstituted or substituted with one or two or three or four of independently selected R23, OR23, SR23, S(O)R23SO2R23, C(O)R23, CO(O)R23, OC(O)R23, OC(O)OR23, NH2, NHR23, N(R23)2, NHC(O)R23, NR23C(O)R23, NHS(O)2R23, NR23S(O)2R23, NHC(O)OR23, NR23C(O)OR23, NHC(O)NH2, NHC(O)NHR23, NHC(O)N(R23)2, NR23C(O)NHR23, NR23C(O)N(R23)2, C(O)NH2, C(O)NHR23, C(O)N(R23)2, C(O)NHOH, C(O)NHOR23, C(O)NHSO2R23, C(O)NR23SO2R23, SO2NH2, SO2NHR23, SO2N(R23)2, C(O)H, C(O)OH, C(N)NH2, C(N)NHR23, C(N)N(R23)2, CNOH, CNOCH3, OH, (O), CN, N3, NO2, CF3, CF2CF3, OCF3, OCF2CF3, F, Cl, Br or I; wherein each R23 is R24, R25, R26, R27 or R28; R24 is spirocycloalkyl or spiroheterocycloalkyl; R25 is aryl; R26 is heteroaryl; R27 is cycloalkyl, cycloalkenyl, or heterocyclyl; R28 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R29, OR29, SR29, S(O)2R29, C(O)OH, NH2, NHR29N(R29)2, C(O)R29, C(O)NH2, C(O)NHR29, C(O)N(R29)2, NHC(O)R29, NR29C(O)R29, NHC(O)OR29, NR29C(O)OR29, NHS(O)2R29, NR29S(O)2R29, OH, (O), F, Cl, Br or I; wherein each R29 is alkyl, alkenyl or alkynyl each of which is unsubstituted or substituted with one or two of independently selected F, Cl, Br or I; wherein the moieties represented by R24, R25, R26, and R27 are independently unsubstituted or substituted with one or two of independently selected R30, OR+, C(O)R30, C(O)OR30, OH, (O), C(O)OH, CN, CF3, OCF3, CF2CF3, F, Cl, Br or I; and R30 is alkyl alkenyl, or alkynyl. |
