STRAIN INDEPENDENT ANTI-INFLUENZA PEPTIDES FOR TARGETING A NOVEL DRUG SITE IN HEMAGGLUTININ TRIMER

摘要

The invention relates to the generation of solution structural model of influenza hemagglutinin trimer having full glycosylation to identify a novel druggable site and design peptides reactive to this drug site and experimentally evaluate ability of the peptides to block pH-induced shape change/aggregation of the hemagglutinin (HA) protein. These peptides and their analogs block the fusion of the HA protein with its receptors in the endosome of host cells in a strain independent manner.