BIOMARKERS FOR CARDIOVASCULAR SIDE-EFFECTS INDUCED BY COX-2 INHIBITORY COMPOUNDS

摘要

The present invention is directed to methods for detecting the presence of minimal or early vasculitis or other vasculopathies induced by a cox-2 inhibitor in a subject to whom a cox-2 inhibitor has been administered, selection of cox-2 inhibitory compounds, use of a cox-2 inhibitory compounds in the manufacture of anti-inflammatory medicaments, and vaccination strategies.

主权项

1. A method for detecting the presence of minimal or early vasculitis or other vasculopathies in a subject, comprising the steps of:
(a) obtaining a sample from a subject to whom a compound or drug, susceptible to induce cardiovascular pathologies has been administered or a subject with a vascular autoimmune disorder; (b) analysing the sample for the presence of a biomarker of minimal or early vasculitis or other vasculopathies; and (c) determining whether the subject has minimal or early vasculitis or other vasculopathies based upon the presence of absence of a biomarker of minimal or early vasculitis or other vasculopathies.