| 发明名称 |
YEAST CELL WITH INACTIVATED GLYCEROL-3-PHOSPHATE DEHYDROGENASE AND ACTIVATED GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE AND METHOD OF PRODUCING LACTATE USING THE SAME |
| 摘要 |
A genetically modified yeast cell comprising increased glyceraldehyde-3-phosphate dehydrogenase activity converting glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate as compared to a parent yeast cell of the same type, and reduced glycerol-3-phosphate dehydrogenase activity converting dihydroxyacetone phosphate to glycerol-3-phosphate compared to a parent yeast cell of the same type, and related compositions and methods. |
| 申请公布号 |
US2015152447(A1) |
申请公布日期 |
2015.06.04 |
| 申请号 |
US201414559426 |
申请日期 |
2014.12.03 |
| 申请人 |
Samsung Electronics Co., Ltd. |
发明人 |
Kim Sungsoo;Song Jiyoon;Kang Changduk;Lee Juyoung;Lee Seunghyun;Cho Kwangmyung |
| 分类号 |
C12P7/56;C12N9/04;C12N15/81;C12N9/02 |
主分类号 |
C12P7/56 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically modified yeast cell comprising increased glyceraldehyde-3-phosphate dehydrogenase activity in converting glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate as compared to a parent yeast cell not having an increased glyceraldehyde-3-phosphate dehydrogenase activity, and a deletion or disruption mutation of a gene encoding a polypeptide that converts dihydroxyacetone phosphate to glycerol-3-phosphate, and glycerol-3-phosphate dehydrogenase activity in converting dihydroxyacetone phosphate to glycerol-3-phosphate is reduced compared to a parent yeast cell not having a deletion or disruption mutation of the gene encoding a polypeptide that converts dihydroxyacetone phosphate to glycerol-3-phosphate. |
| 地址 |
Suwon-si KR |
