| 发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION |
| 摘要 |
Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof. |
| 申请公布号 |
US2015152411(A1) |
申请公布日期 |
2015.06.04 |
| 申请号 |
US201314403557 |
申请日期 |
2013.05.23 |
| 申请人 |
Isis Pharmaceuticals, Inc. |
发明人 |
Crooke Rosanne M.;Graham Mark J.;Freier Susan M. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound comprising a modified oligonucleotide consisting of 14 to 30 linked nucleosides and comprising a nucleobase sequence comprising a portion of at least 14 contiguous nucleobases complementary to an equal length portion of nucleobases 3900 to 3923 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 80% complementary to SEQ ID NO: 1. |
| 地址 |
Carlsbad CA US |
