发明名称 ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
摘要 PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of PI3K, particularly of PI3Kγ.SOLUTION: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising the compounds, and methods of using the compositions in treatment of various disease, conditions, or disorders. A composition may comprise a pharmaceutically acceptable carrier, adjuvant, or vehicle, and may further include a therapeutic agent such as an agent for treating multiple sclerosis, an anti-inflammatory agent, an immunomodulatory agent, or an immunosuppressive agent.
申请公布号 JP2015101589(A) 申请公布日期 2015.06.04
申请号 JP20150034849 申请日期 2015.02.25
申请人 VERTEX PHARMACEUTICALS INC 发明人 ARONOV ALEX;COME JON H;ROBERT J DAVIES;PIERCE ALBERT C;WANG JIAN;SUGANTHINI NANTHAKUMAR;CAO JINGRONG;UPUL K BANDARAGE;ELAINE KRUEGER;ARNAUD LE TIRAN;LIAO YUSHENG;DAVID MESSERSMITH;PHILIP N COLLIER;RONALD GERY JR;HARDWIN O'DOWD;JAMES A HENDERSON;ANNE-LAURE GRILLOT
分类号 C07D401/04;A61K31/136;A61K31/4439;A61K31/444;A61K31/4545;A61K31/4709;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61K38/00;A61K38/21;A61K39/395;A61K45/00;A61P21/02;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P29/00;A61P37/02;A61P43/00;C07D401/14;C07D403/14;C07D405/14;C07D409/14;C07D417/14;C07D471/04;C07D471/10;C07D491/20 主分类号 C07D401/04
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