METHOD FOR NUCLEAR MAGNETIC RESONANCE DIFFUSION MEASUREMENTS

摘要

A method and system for determining a property of a substance using nuclear magnetic resonance (NMR) is described herein. The method includes applying a NMR pulse sequence to the substance. The NMR pulse sequence includes a first set of pulses and a second set of pulses. The first set of pulses and the second set of pulses encode for overlapping diffusion times. By overlapping diffusion times, the NMR pulse sequence can be used to measure a diffusion coefficient for a first diffusion time, a diffusion coefficient for a second diffusion time, and a correlation between the two overlapping diffusion times. This information, in turn, can be used to differentiate between intrinsic bulk diffusivity of the substance and the reduced diffusivity of the substance caused by restricted diffusion.

主权项

1. A method comprising:
applying a nuclear magnetic resonance (NMR) pulse sequence comprising a first set of pulses and a second set of pulses to a substance, wherein the first set of pulses encode for a first diffusion time and the second set of pulses encode for a second diffusion time, the first diffusion time overlapping the second diffusion time; detecting a NMR signal produced by the NMR pulse sequence to obtain NMR signal data; applying to the substance a modified NMR pulse sequence generated by changing at least one of (a) the first diffusion time and (b) the second diffusion time; detecting a NMR signal produced by the modified NMR pulse sequence to obtain NMR signal data; and determining a property of the substance using at least the NMR signal data over each of the overlapping diffusion times for the NMR pulse sequence and the modified NMR pulse sequence.