Low-Molecular-Weight Biotechnological Chondroitin 6-Sulphate for Prevention of Osteoarthritis

摘要

Disclosed is a low-molecular-weight (1000-5000 daltons) chondroitin sulphate (CS) produced by chemical sulphation and subsequent depolymerisation of a non-sulphated chondroitin backbone obtained with biotechnology techniques. The CS described is substantially monosulphated, mainly at the 6-position, with very little sulphation at the 4-position, and with a mono/disulphated disaccharide ratio and charge density similar to those of natural CS. Said biotechnological chondroitin 6-sulphate (C6S) is useful in the treatment and prevention of osteoarthritis and in acute and chronic inflammatory processes.

主权项

1. A chondroitin sulphate having a molecular weight ranging from 1000 to 5000 daltons having anti-inflammatory and anti-arthritic biological activity comprising at least about 65% by weight disaccharide 6-monosulphate, less than about 1% by weight disaccharide 4-monosulphate, about 20% by weight or less disaccharide 2,6-disulphate, less than about 5% by weight disaccharide 4,6-disulphate, less than about 1% by weight disaccharide 2,4-disulphate, less than about 15% by weight non-sulphated disaccharide, and a charge density value ranging from about 1 to about 1.25.