COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF NEOPLASTIC DISEASE IN A MAMMALIAN SUBJECT

摘要

Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to a human endogenous retrovirus type E antigen on a tumor cell. A method of treating a neoplastic disease in a mammalian subject is provided which comprises administering to a mammalian subject a composition comprising an enriched immune cell population reactive to a human endogenous retrovirus type E antigen, in an amount effective to reduce or eliminate the neoplastic disease or to prevent its occurrence or recurrence.

主权项

1. A composition comprising a CD8+ T cell population or a dendritic cell population reactive to a human endogenous retrovirus type E antigen present on a renal cell carcinoma cell,
wherein the antigen comprises at least 10 contiguous amino acids encoded by a nucleic acid molecule comprising a nucleotide sequence that is at least 80% identical to the nucleotide sequence set forth in SEQ ID NO:45 or the antigen comprises at least 10 contiguous amino acids encoded by a nucleic acid molecule comprising a nucleotide sequence that is at least 80% identical to the nucleotide sequence set forth in SEQ ID NO:47.