摘要 |
The present invention relates to a benzoxazinon derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating urotensin-II receptor hyperactivity-related diseases containing the same as an active ingredient. The benzoxazinon derivative according to the present invention acts as an antagonist of a urotensin-II receptor, and thus can be usefully used for preventing, ameliorating or treating urotensin-II receptor hyperactivity-related diseases such as congestive heart failure, heart ischemia, myocardial infarction, cardiomegalia, myofibrosis cordis, coronary artery disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, degenerative neuronal disease, stroke, pain, depression, mental illness, and cancer. |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
LEE, BYUNG HO;YI, KYU YANG;OH, KWANG-SEOK;LIM, CHAE JO;LEE, JEONG HYUN;KIM, NACK JEONG;SUH, JEE HEE;SEO, HO WON |