发明名称 N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
摘要 The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
申请公布号 US2015152050(A1) 申请公布日期 2015.06.04
申请号 US201314402232 申请日期 2013.05.17
申请人 Bayer Pharma Aktiengesellschaft 发明人 Lampe Thomas;Hahn Michael;Stasch Johannes-Peter;Schlemmer Karl-Heinz;Wunder Frank;El Sheikh Sherif;Li Volkhart Min-Jian;Becker-Pelster Eva Maria;Stoll Friederike;Knorr Andreas
分类号 C07D211/14;A61K45/06;A61K31/472;A61K31/438;A61K31/451;C07D217/04;A61K31/445;C07D221/20 主分类号 C07D211/14
代理机构 代理人
主权项 1. Compound of the formula (I) in which R1A and R1B independently of one another represent hydrogen, methyl, ethyl or n-propyl orare attached to one another and together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, R2A represents hydrogen, methyl, ethyl, n-propyl, isopropyl, cyclopropyl, methoxy, ethoxy or cyclopropyloxy, R2B represents hydrogen or methyl, or R2A and R2B are attached to one another and together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, R3 represents hydrogen, fluorine, chlorine, methyl, trifluoromethyl or ethyl, R4A and R4B independently of one another represent methyl, trifluoromethyl or ethyl orare attached to one another and together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl or cyclopentyl ring which may be substituted up to two times by fluorine and A represents an optionally substituted or fused piperidine ring of the formula  wherein * denotes the point of attachment to the remainder of the molecule,R5A represents hydrogen, (C1-C4)-alkyl, cyclopropyl, cyclobutyl, methoxy, ethoxy or phenyl, where (C1-C4)-alkyl for its part may be substituted up to three times by fluorine,R5B represents hydrogen or methyl,orR5A and R5B are attached to one another and together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring,andR6 represents hydrogen, fluorine, chlorine, methyl or trifluoromethyl,and their salts, solvates and solvates of the salts.
地址 Berlin DE