发明名称 |
SUBSTITUTED 4-BENZYL-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-2CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1 |
摘要 |
In one aspect, the invention relates to N-substituted 3,4-dihydro-benzo[£][l,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
WO2015080904(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
WO2014US66206 |
申请日期 |
2014.11.18 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
LINDSLEY, CRAIG, W.;CONN, P., JEFFREY;STAUFFER, SHAUN, R.;PANARESE, JOSEPH, D. |
分类号 |
A61K31/5383 |
主分类号 |
A61K31/5383 |
代理机构 |
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代理人 |
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地址 |
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